Approved Uses

Otezla (apremilast) is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

Otezla is a different kind of treatment Close
A pill that can help
you achieve clearer skin

Treat plaque psoriasis differently

Treat psoriatic arthritis differently

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Otezla for moderate to severe
plaque psoriasis
Otezla for psoriatic arthritis
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*Certain restrictions apply. *Certain restrictions apply; eligibility not based on income.

APPROVED USES

Otezla® (apremilast) is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

IMPORTANT SAFETY INFORMATION

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of having diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

Otezla is associated with an increase in depression. In clinical studies, some patients reported depression, or suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression, or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.

Some medicines may make Otezla less effective, and should not be taken with Otezla. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines.

Side effects of Otezla include diarrhea, nausea, vomiting, upper respiratory tract infection, runny nose, sneezing, or congestion, abdominal pain, tension headache, and headache. These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed. Otezla has not been studied in pregnant women or in women who are breastfeeding.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088.

Please click here for Full Prescribing Information.

Types of plaque psoriasis treatments

Though many people assume that plaque psoriasis is just a skin disease, it actually starts inside the body—so it's important to keep that in mind.

If you’ve been living with plaque psoriasis for a while, you and your dermatologist have probably tried a lot of different things to treat it. Most (though not all) treatments for plaque psoriasis fall into 2 categories: systemic or non-systemic. Systemic treatments are generally taken as pills or injections. Non-systemic treatments are generally applied directly to the skin’s surface.

Systemic
treatments

Treatments that work inside the body to help reduce plaque psoriasis symptoms. Systemic medications include:

  • Oral medications: Pills, tablets, or capsules taken by mouth. Otezla is one of these.
  • Injectable biologics: Medications that are injected into the body to act on a specific function of the immune system.

Non-systemic
treatments

Treatments that are applied to the skin's surface to help reduce plaque psoriasis symptoms. Non-systemic medications include:

  • Topical medications: Creams, lotions, and salves that are applied to the skin's surface to help reduce symptoms.
  • Phototherapy: Also known as light therapy, phototherapy involves exposing the skin to ultraviolet light on a regular basis.

Otezla is different. It’s a pill that can help you get clearer skin

If your plaque psoriasis isn’t responding to topical treatments as well as you would like, or if you are seeking options, it may be time for you and your doctor to consider something different.

Otezla is unique in that it works inside the body to help reduce inflammation.

Otezla is the only anti-inflammatory of its kind: It’s the only PDE4 inhibitor approved to treat moderate to severe plaque psoriasis.

See how Otezla works

5 Reasons to consider Otezla

  1. Otezla is not an injection, biologic, or cream—it’s a pill that treats plaque psoriasis differently
  2. 75% clearer skin is achievable in some people after just 4 months, with reduced redness, thickness, and scaliness of plaques
  3. Otezla works inside the body to help reduce inflammation
  4. The majority of people pay $0 a month* for the #1 prescribed branded pill for plaque psoriasis†
  5. The Otezla Prescribing Information has no requirement for initial or routine blood testing
Results with Otezla

*Certain restrictions apply; eligibility not based on income.
†Source: Symphony Health Solutions PrescriberSource PatientFocus data, Celgene proprietary methodology. Jan2016—Jan2019. Data include only oral formulations for scripts tagged with a plaque psoriasis indication.

Meet Jennifer

Jennifer's plaque psoriasis symptoms made her self-conscious. With Otezla, she's living differently.

Watch her story
SEE MORE

*Certain restrictions apply. *Certain restrictions apply; eligibility not based on income.

APPROVED USES

Otezla® (apremilast) is a prescription medicine approved for the treatment of patients with moderate to severe plaque psoriasis for whom phototherapy or systemic therapy is appropriate.

Otezla is a prescription medicine approved for the treatment of adult patients with active psoriatic arthritis.

IMPORTANT SAFETY INFORMATION

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of having diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

Otezla is associated with an increase in depression. In clinical studies, some patients reported depression, or suicidal behavior while taking Otezla. Some patients stopped taking Otezla due to depression. Before starting Otezla, tell your doctor if you have had feelings of depression, or suicidal thoughts or behavior. Be sure to tell your doctor if any of these symptoms or other mood changes develop or worsen during treatment with Otezla.

Some patients taking Otezla lost body weight. Your doctor should monitor your weight regularly. If unexplained or significant weight loss occurs, your doctor will decide if you should continue taking Otezla.

Some medicines may make Otezla less effective, and should not be taken with Otezla. Tell your doctor about all the medicines you take, including prescription and nonprescription medicines.

Side effects of Otezla include diarrhea, nausea, vomiting, upper respiratory tract infection, runny nose, sneezing, or congestion, abdominal pain, tension headache, and headache. These are not all the possible side effects with Otezla. Ask your doctor about other potential side effects. Tell your doctor about any side effect that bothers you or does not go away.

Tell your doctor if you are pregnant, planning to become pregnant or planning to breastfeed. Otezla has not been studied in pregnant women or in women who are breastfeeding.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-332-1088.

Please click here for Full Prescribing Information.

Important Safety Information

See more

You must not take Otezla if you are allergic to apremilast or to any of the ingredients in Otezla.

Otezla can cause severe diarrhea, nausea, and vomiting, especially within the first few weeks of treatment. Use in elderly patients and the use of certain medications with Otezla appears to increase the risk of having diarrhea, nausea, or vomiting. Tell your doctor if any of these conditions occur.

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